Bridging the Gap between Preclinical and Clinical Studies Using Pharmacokinetic-Pharmacodynamic Modeling: An Analysis of GDC-0973, a MEK Inhibitor

TitleBridging the Gap between Preclinical and Clinical Studies Using Pharmacokinetic-Pharmacodynamic Modeling: An Analysis of GDC-0973, a MEK Inhibitor
Publication TypeJournal Article
Year of Publication2012
AuthorsWong H., Vernillet L., Peterson A., Ware J.A, Lee L., Martini J.-F., Yu P., Li C., Rosario G.D, Choo E.F, Hoeflich K.P, Shi Y., Aftab B.T, Aoyama R., Lam S.T, Belvin M., Prescott J.
JournalClinical Cancer Research
Volume18
Issue11
Pagination3090 - 3099
Date Published06/2012
ISSN1078-0432
URLhttp://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0432.CCR-12-0445
DOI10.1158/1078-0432.CCR-12-0445
Short TitleClinical Cancer Research