Chloroform compatible, thiol-ene based replica molded micro chemical devices as an alternative to glass microfluidic chips.

TitleChloroform compatible, thiol-ene based replica molded micro chemical devices as an alternative to glass microfluidic chips.
Publication TypeJournal Article
Year of Publication2019
AuthorsGeczy R, Sticker D, Bovet N, Häfeli UO, Kutter JP
JournalLab Chip
Volume19
Issue5
Pagination798-806
Date Published02/2019
ISSN1473-0189
Abstract

Polymeric microfluidic chips offer a number of benefits compared to their glass equivalents, including lower material costs and ease and flexibility of fabrication. However, the main drawback of polymeric materials is often their limited resistance to (organic) solvents. Previously, thiol-ene materials were shown to be more solvent resistant than most other commonly used polymers; however, they still fall short in "harsh" chemical environments, such as when chlorinated solvents are present. Here, we show that a simple yet effective treatment of thiol-ene materials results in exceptional solvent compatibility, even for very challenging chemical environments. Our approach, based on a temperature treatment, results in a 50-fold increase in the chloroform compatibility of thiol-enes (in terms of longevity). We show that prolonged heat exposure allows for the operation of the microfluidic chips in chloroform for several days with no discernable deformation or solvent-induced swelling. The method is applicable to many different thiol-ene-based materials, including commercially available formulations, and also when using other commonly considered "harsh" solvents. To demonstrate the utility of the solvent compatible thiol-enes for applications where chloroform is frequently employed, we show the continuous and uniform production of polymeric microspheres for drug delivery purposes over a period of 8 hours. The material thus holds great promise as an alternative choice for microfluidic applications requiring harsh chemical environments, a domain so far mainly restricted to glass chips.

DOI10.1039/c8lc01260a
Alternate JournalLab Chip
PubMed ID30688958