2023
Brown JI, Wang P, Wong AYL, Petrova B, Persaud R, Soukhtehzari S, Lopez McDonald M, Hanke D, Christensen J, Iliev P, Wang W, Everton DK, Williams KC, Frank DA, Kanarek N, Page BDG. Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity. Metabolites. 2023.13(2):151. [IF:5.5, SJR: 0.95]
Javed S, Soukhtehzari S, Salmond N, Fernandes N, and Williams KC*. Development of an In Vivo System to Model Breast Cancer Metastatic Organotropism and Evaluate Treatment Response using the Chick Embryo iScience. 2023. 26(4):106305. [This is a new Cell family journal with its first IF] [IF:6.3, SJR: 1.97]
Ajaykumar A, Caloren LC, Povshedna T, Hsieh AYY, Zakaria A, Cai R, Smith MSR, Thompson CAH, Becquart P, Uday P, Pattanshetti R, Quandt JA, Wong JMY and Cote HCF. Dolutegravir-containing HIV therapy reversibly alters mitochondrial health and morphology in cultured human fibroblasts and peripheral blood mononuclear cells. AIDS 37(1):19-32 doi: 10.1097/QAD.0000000000003369 (2023).
Sidor, N, Velenosi T, Lajoie G, Filler G, House A, Weir M, Thomson B, Garg A, Renaud J, McDowell T, Knauer M, Tirona R, Noble R, Selby N, Taal M, Urquhart B. Investigation of N,N,N-trimethyl-L-alanyl-L-proline betaine (TMAP) as a biomarker of kidney function. ACS Omega. 2023 Apr 21;8(17):15160-15167. PMID: 37151562
2022
Tan MJ, Fernandes N, Williams KC, Ford NL. In vivo micro-computed tomography imaging in liver tumor study of mice using Fenestra VC and Fenestra HDVC. Scientific Reports. 2022. 12 (1), 1-9. [IF:5.6, SJR: 1.01]
Javed S, Soukhtehzari S, Fernandes N, and Williams KC*. Longitudinal Bioluminescence Imaging to Monitor Breast Tumor Growth and Treatment Response using the Chick Chorioallantoic Membrane Model. Scientific Reports. 2022. 12 (1), 1-10. [IF:4.9, SJR: 1.01]
Soukhtehzari S, Berish RB, Fazli L, Watson PH, and Williams KC*. The Different Prognostic Significance of Polysialic Acid and CD56 Expression in Tumor Cells and Lymphocytes Identified in Breast Cancer. NPJ Breast Cancer. 2022 Jul 2;8(1):78. [IF:7.7, SJR: 2.86]
Yang SY, Monchaud D and Wong JMY. Global mapping of RNA G-quadruplexes (G4-RNAs) using G4RP-seq. Nat. Protocol. 17(3):870-889. doi: 10.1038/s41596-021-00671-6 (2022)
Velenosi TJ†, Krausz KW, Hamada K, Dorsey TH, Ambs S, Takahashi S, Gonzalez FJ†. Pharmacometabolomics reveals urinary diacetylspermine as a biomarker of doxorubicin effectiveness in breast cancer. NPJ Precis Oncol 2022 Oct 7;6(1):70. PMID: 36207498
Velenosi TJ, Ben-Yakov G, Podzsun M, Hercun J, Etzion O, Yang S, Nadal C, Haynes-Williams V, Huang WCA, Gonzalez-Hodar L, Brychta RJ, Takahashi S, Akkaraju V, Krausz KW, Walter, Cai H, Walter PJ, Muniyappa R, Chen KY, Gonzalez FJ, Rotman Y. Postprandial plasma lipidomics reveal specific alteration of hepatic-derived diacylglycerols in non-alcoholic fatty liver disease. Gastroenterology 2022 Mar 10;S0016-5085(22)00235-9. PMID 35283114
Meister J, Bone DBJ, Knudsen JR, Barella LF, Velenosi TJ, Akhmedov D, Lee Regina, Cohen A, Gavrilova O, Cui Y, Karsenty G, Chen M, Weinstein LS, Kleinert M, Berdeaux R, Jensen TE, Richter EA, Wess J. Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells. Nat Commun. 2022 Jan 10;13(1):22 PMID: 35283114V
2021
Doerksen MJ, Jones RS, Coughtrie MWH, and Collier AC. Parameterization of Microsomal and Cytosolic Scaling Factors: methodological and biological considerations for scalar derivation and validation. European Journal of Drug Metabolism and Pharmacokinetics 2021 Mar;46(2):173-183. doi: 10.1007/s13318-020-00666-w.
Campbell KSJ, Collier AC, Irvine M, Brain U, Rurak DW, Oberlander TF and Lim K. Maternal Serotonin Reuptake Inhibitor (SRI) antidepressants have acute drug effects on third-trimester fetal heart rate variability. Frontiers in Psychiatry July 30 2021 doi: 10.3389/fpsyt.2021.680177
Takahashi, RH, Forrest W, Smith AD, Badee J, Qiu N, Schmidt S, Collier AC, Parrott N, Fowler S Characterization of Hepatic UDP-Glucuronosyl Transferase Enzyme Abundance - Activity Correlations and Population Variability using a Proteomics Approach. Drug Metab Dispos. 2021 Jun 29:DMD-AR-2021-000474. doi: 10.1124/dmd.121.000474. Online ahead of print. PMID: 34187837
Rougée LRA, Collier AC, Richmond RH. Chronic exposure to 4-nonylphenol alters UDP-glucuronosyl transferase and sulfotransferase clearance of steroids in the hard coral, Pocillopora damicornis Frontiers in Physiology February 2021 doi: 10.3389/fphys.2021.608056
Mer AS, Heath EM, Madani Tonekaboni SA, Dogan-Artun N, Nair SK, Murison A, et al. Biological and therapeutic implications of a unique subtype of NPM1 mutated AML. Nat Commun. 2021 Feb 16;12(1):1054.
Fekadu A, Oppenheim C, Manyazewal T, Nislow C, Woldeamanuel Y, Hailu A, et al. Understanding the key processes of excellence as a prerequisite to establishing academic centres of excellence in Africa. BMC Med Educ. 2021 Jan 7;21(1):36.
A genome-wide portrait of pervasive drug contaminants. Scientific Reports, J. Ogbede, G. Giaever, C. Nislow (2021)
Salmond, N, Khanna K, Owen, G, Williams, KC. Nanoscale Flow Cytometry of Extracellular Vesicles in Plasma: Important Technical Considerations of an Emerging Liquid Blood Biopsy Technology. Nanoscale. 2021 Jan 28;13(3):2012-2025. *specially selected and featured in an Editor’s Choice web collection focusing on recent breakthroughs in nanobiotechnology*
Khanna K, Salmond N, Lynn KS, Leong HS, Williams KC. Clinical Significance of STEAP1 Extracellular Vesicles in Prostate Cancer. Prostate Cancer Prostatic Dis. 2021. doi: 10.1038/s41391-021-00319-2
Yang SY, Chang EY, Lim J, Kwan HH, Monchaud D, Yip S, Stirling PC and Wong JMY. G-quadruplexes mark alternative lengthening of telomeres. NAR Cancer 3(3) doi.org/10.1093/narcan/zcab031(2021)
Xu JL, de Oliveira DM, Trudeau MA, Chin JY, Sin D, Sandford A and Wong JMY. Mild Catalytic Defects of TERT Polymorphism rs61748181 Affect the Clinical Presentation of Chronic Obstructive Pulmonary Disease. Sci Rep 11(1):4333. doi: 10.1038/s41598-021-83686-z. (2021)
Salmond N and Williams KC*. Isolation and characterization of extracellular vesicles for clinical applications in cancer–time for standardization? 2021 Nanoscale Advances 3, 1830-1852. [IF:5.1, SJR: 1.01].
Salmond, N, Khanna K, Owen, G, Williams, KC*. Nanoscale Flow Cytometry of Extracellular Vesicles in Plasma: Important Technical Considerations of an Emerging Liquid Blood Biopsy Technology. Nanoscale. 2021 Jan 28;13(3):2012-2025. [IF:8.3, SJR: 2.18]. # citations: 9. §Specially selected and featured in an Editor’s Choice web collection focusing on recent breakthroughs in nanobiotechnology
Khanna K, Salmond N, Lynn KS, Leong HS,* Williams KC*. Clinical Significance of STEAP1 Extracellular Vesicles in Prostate Cancer. Prostate Cancer Prostatic Dis. 2021. [IF:5.5, SJR:1.52].
Yang SY, Chang EY, Lim J, Kwan HH, Monchaud D, Yip S, Stirling PC and Wong JMY. G-quadruplexes mark alternative lengthening of telomeres. NAR Cancer 3(3):zcab031. doi: 10.1093/narcan/zcab031. eCollection 2021 Sep.doi.org/10.1093/narcan/zcab031(2021)
Xu JL, de Oliveira DM, Trudeau MA, Chin JY, Sin D, Sandford A and Wong JMY. Mild Catalytic Defects of TERT Polymorphism rs61748181 Affect the Clinical Presentation of Chronic Obstructive Pulmonary Disease. Sci Rep 11(1):4333. doi: 10.1038/s41598-021-83686-z. (2021)
2020
Price HR, Lai D#, Kim H, Coughtrie MWH and Collier AC. Detection and quantitation of non-steroidal anti-inflammatory drug use close to the time of birth using umbilical cord tissue. Toxicology Reports (2020) Sep 8;7:1311-1318. doi: 10.1016/j.toxrep.2020.09.003.
Smith ADH, Page, Brent DG, Collier AC and Coughtrie MWH. Homology modeling of human UDP-glucuronosyltransferase 1A6 reveals insights into factors influencing substrate and co-substrate binding. ACS Omega 2020 Mar 20;5(12):6872-6887.
Knight SJ, Smith ADH, Kim H and Collier AC. Human placental suppressors of cytokine signalling (SOCS) and inflammatory cytokines are dysregulated in assisted reproduction, advanced maternal age and pre-term birth. Clinical and Experimental Obstetrics and Gynecology 2020; 47(2), 277-286 (Cover image)
Price HR, Chehroudi C, Knight SJ, Smith AD, Lai D#, Kim H, Wright TE, Coughtrie MWH and Collier AC. Umbilical cord as an analytical matrix – a technical note. Placenta 2020; 90:42-44. doi: 10.1016/j.placenta.2019.12.001
Liu Y, Badée J, Takahashi RH, Schmidt S, Parrot N, Fowler S, Mackenzie PI, Coughtrie MWH, Collier AC. Co-expression of human hepatic uridine diphosphate glucuronosyltransferase (UGT) proteins: Implications for ontogenetic mechanisms and isoform co-regulation. J Clin Pharmacol 60, 722-733 (2020).
Ul Ain Q, Campos E, Huyhn A, Witzigmann D, *Hedtrich S.: Gene delivery to the skin - How far have we come? Trends in Biotechnology. https://doi.org/10.1016/j.tibtech.2020.07.012.
Adhikary PP, Tan Z, Page BDG, *Hedtrich S.: TSLP as druggable target - a silver-lining for atopic diseases? Pharmacol Ther. 2020: 107648.
Jevtić M, Löwa A, Nováčková A, Kováčik A, Kaessmeyer S, Erdmann G, Vávrová K, *Hedtrich S.: Impact of intercellular crosstalk between epidermal keratinocytes and dermal fibroblasts on skin homeostasis. Biochim Biophys Acta Mol Cell Res; 1867: 118722.
Löwa A, Graff P, Kaessmeyer S, *Hedtrich S.: Fibroblasts from atopic dermatitis patients trigger inflammatory processes and hyperproliferation in human skin equivalents. J Eur Acad Dermatol Venereol. 2020 Jan 28. doi: 10.1111/jdv.16240.
Peigneux A, Glitscher EA, Charbaji R, Weise C, Wedepohl S, Calderón M, *Jimenez-Lopez C, *Hedtrich S.: Protein corona formation and its influence on biomimetic magnetite nanoparticles. J Mater Chem B. 2020. doi: 10.1039/c9tb02480h.
Rashmi, Zabihi F, Singh AK, Achazi K, Schade B, Hedtrich S, Haag R, Sharma SK.: Non-ionic PEG-oligoglycerol dendron conjugated nano-carriers for dermal drug delivery. Int J Pharm. 2020; 580:119212. doi: 10.1016/j.ijpharm.2020.119212.
Elpelt A, Ivanov D, Nováčková A, Kováčik A, Sochorová M, Saeidpour S, Teutloff C, Lohan SB, Lademann J, Vávrová K, Hedtrich S, Meinke MC.: Investigation of TEMPO partitioning in different skin models as measured by EPR spectroscopy - Insight into the stratum corneum. J Magn Reson. 2020; 310:106637.
Maharaj AR, Wu H, Hornik CP, Balevic SJ, Hornik CD, Smith PB, Gonzalez D, Zimmerman KO, Benjamin DK Jr, Cohen-Wolkowiez M. Simulated Assessment of Pharmacokinetically Guided Dosing for Investigational Treatments of Pediatric Patients With Coronavirus Disease 2019. JAMA Pediatr. 2020 Oct 1;174(10):e202422. doi: 10.1001/jamapediatrics.2020.2422.
Hill KD, Maharaj AR, Li JS, Thompson E, Barker PCA, Hornik CP. A Randomized, Controlled Pharmacokinetic and Pharmacodynamics Trial of Ambrisentan After Fontan Surgery. Pediatr Crit Care Med. 2020 Sep;21(9):e795-e803. doi: 10.1097/PCC.0000000000002410.
Maharaj AR, Wu H, Zimmerman KO, Autmizguine J, Kalra R, Al-Uzri A, Sherwin CMT, Goldstein SL, Watt K, Erinjeri J, Payne EH, Cohen-Wolkowiez M, Hornik CP. Population pharmacokinetics of olanzapine in children. Br J Clin Pharmacol. 2020 Jun 4;. doi: 10.1111/bcp.14414.
Maharaj AR, Wu H, Hornik CP, Arrieta A, James L, Bhatt-Mehta V, Bradley J, Muller WJ, Al-Uzri A, Downes KJ, Cohen-Wolkowiez M. Use of normalized prediction distribution errors for assessing population physiologically-based pharmacokinetic model adequacy. J Pharmacokinet Pharmacodyn. 2020 Jun;47(3):199-218. doi: 10.1007/s10928-020-09684-2.
Balevic SJ, Hornik CP, Green TP, Clowse MEB, Gonzalez D, Maharaj AR, Schanberg LE, Eudy AM, Swamy GK, Hughes BL, Cohen-Wolkowiez M. Hydroxychloroquine in Patients with Rheumatic Disease Complicated by COVID-19: Clarifying Target Exposures and the Need for Clinical Trials. J Rheumatol. 2020 May 11;. doi: 10.3899/jrheum.200493.
Greenberg RG, Wu H, Maharaj A, Cohen-Wolkowiez M, Tomashek KM, Osborn BL, Clark RH, Walter EB. A Pharmacoepidemiologic Study of the Safety and Effectiveness of Clindamycin in Infants. Pediatr Infect Dis J. 2020 Mar;39(3):204-210. doi: 10.1097/INF.0000000000002524.
Campagne O, Davis A, Maharaj AR, Zhong B, Stripay J, Farmer D, Roussel MF, Stewart CF. CNS penetration and pharmacodynamics of the CHK1 inhibitor prexasertib in a mouse Group 3 medulloblastoma model. Eur J Pharm Sci. 2020 Jan 15;142:105106. doi: 10.1016/j.ejps.2019.105106.
Findlay Black H, Mastromatteo S, Sinha S, Ehrlich RL, Nislow C, Chang Mell J, et al. A competence-regulated toxin-antitoxin system in Haemophilus influenzae. PLoS One. 2020;15(1):e0217255.
Edouarzin E, Horn C, Paudyal A, Zhang C, Lu J, Tong Z, et al. Broad-spectrum antifungal activities and mechanism of drimane sesquiterpenoids. Microb Cell. 2020 Mar 12;7(6):146–59.
Coutin NPJ, Giaever G, Nislow C. Interactively AUDIT Your Growth Curves with a Suite of R Packages. G3 (Bethesda). 2020 Mar 5;10(3):933–43.
Breaux S, Desrosiers FAD, Neira M, Sinha S, Nislow C. Pharmacogenomics at the Point of Care: A Community Pharmacy Project in British Columbia. J Pers Med. 2020 Dec 24;11(1).
Trivedi, P. C., Bartlett, J. J., Mercer, A., Slade, L., Surette, M., Ballabio, A., Flibotte, S., Hussein, B., Rodrigues, B., Kienesberger, P. C., and Pulinilkunnil, T. C. Loss of function of transcription factor EB remodels lipid metabolism and cell death pathways in the cardiomyocyte. BBA - Molecular Basis of Disease 1866 (10):165832, 2020.
Shang R., Lal, N., Puri, K., Hussein, B., and Rodrigues, B. Involvement of heparanase in endothelial cell-cardiomyocyte crosstalk. In: Heparanase-from basic research to clinical applications. Eds. Vlodavsky, I., Sanderson, R.D., and Ilan, N. Springer International Publishing AG, Switzerland; 1221: 721-745, 2020.
Rodrigues E, Jung J, Park H, Loo C, Soukhtehzari S, Kitova EN, Mozaneh F, Daskhan G, Aghanya V, Sarkar S, Streith L, St. Laurent C, Julien JP, West LC, Williams KC, Klassen JS, Macauley MS. A Versatile Soluble Siglec Scaffold for Sensitive and Quantitative Detection of Glycan Ligands. Nat Commun. 2020 Oct 9;11(1):5091. doi: 10.1038/s41467-020-18907-6.
Medeiros B, Goodale D, Postenka C, Lowes LE, Kiser P, Hearn S, Salmond N, Williams KC and Allan AL. Triple-Negative Primary Breast Tumors Induce Supportive Premetastatic Changes in the Extracellular Matrix and Soluble Components of the Lung Microenvironment. Cancers 2020, 12(1), 172.
Nguyen KTTT and Wong JMY. Telomerase Biogenesis and Activities from the Perspective of Its Direct Interacting Partners. Cancers 12(6), E1679 doi: 10.3390/cancers12061679. (2020)
Thompson CAH and Wong JMY. Non-canonical Functions of Telomerase Reverse Transcriptase: Emerging Roles and Biological Relevance. Curr. Top. Med. Chem. 20(6):498-507 doi: 10.2174/1568026620666200131125110. (2020)
Rodrigues E, Jung J, Park H, Loo C, Soukhtehzari S, Kitova EN, Mozaneh F, Daskhan G, Aghanya V, Sarkar S, Streith L, St. Laurent C, Julien JP, West LC, Williams KC, Klassen JS, Macauley MS. A Versatile Soluble Siglec Scaffold for Sensitive and Quantitative Detection of Glycan Ligands. Nat Commun. 2020 Oct 9;11(1):5091. [IF:15, SJR:4.84].
Medeiros B, Goodale D, Postenka C, Lowes LE, Kiser P, Hearn S, Salmond N, Williams KC and Allan AL. Triple-Negative Primary Breast Tumors Induce Supportive Premetastatic Changes in the Extracellular Matrix and Soluble Components of the Lung Microenvironment. Cancers 2020, 12(1), 172. [IF:6.1, SJR:1.34].
Nguyen KTTT and Wong JMY. Telomerase Biogenesis and Activities from the Perspective of Its Direct Interacting Partners. Cancers 12(6), E1679 doi: 10.3390/cancers12061679. (2020)
Thompson CAH and Wong JMY. Non-canonical Functions of Telomerase Reverse Transcriptase: Emerging Roles and Biological Relevance. Curr.Top.Med.Chem. 20(6):498-507. doi: 10.2174/1568026620666200131125110. (2020)
2019
Liu Y, Badeé J, Takahashi, RH, Schmidt S, Parrott N, Fowler S, Mackenzie PI, Coughtrie MWH, and Collier AC, Co-expression of human hepatic uridine diphosphate glucuronosyltransferase (UGT) proteins: Implications for ontogenetic mechanisms and isoform co-regulation. Journal of Clinical Pharmacology 2019 Dec 26. doi: 10.1002/jcph.1571.
Chehroudi C, Kim H, Wright TE, Collier, AC. Dysregulation of inflammatory cytokines and inhibition of VEGFA in the human umbilical cord are associated with negative pregnancy outcomes. Placenta 2019; 87:16-22. doi: 10.1016/j.placenta.2019.09.002.
Brunklaus A, Schorge S, Smith AD, Ghanty I, Stewart K, Gardiner S, Du J, Pérez-Palma E, Symonds JD, Collier AC, Lal D, Zuberi SM. SCN1A variants from bench to bedside-improved clinical prediction from functional characterization. Human Mutation. 2019 Nov 28. doi: 10.1002/humu.23943. [Epub ahead of print]
Badée J, Qiu N, Collier AC, Takahashi RH, Forrest W, Parrott N, Schmidt S and Fowler S. Characterization of the Ontogeny of Hepatic UDP-Glucuronsyl Transferase Enzymes Based on Glucuronidation Activity Measured in Human Liver Microsomes. The Journal of Clinical Pharmacology 2019 Sep;59 Suppl 1:S42-S55. doi: 10.1002/jcph
Murphy JWA, Collier AC and Richmond RH. Antioxidant enzyme cycling over reproductive lunar cycles in Pocillopora damicornis PeerJ. 2019 Jun 7;7:e7020. doi: 10.7717/peerj.7020.
Badée J, Qiu N, Parrott P, Collier AC, Schmidt S and Fowler S. Optimization of Experimental Conditions of Automated Glucuronidation Assays in Human Liver Microsomes using a Cocktail Approach and Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry. Drug Metabolism and Disposition 2019;47(2):124-134. doi: 10.1124/dmd.118.084301.
Knight SJ, Smith AD, Wright TE, Collier AC. Detection of opioids in umbilical cord lysates: an antibody-based rapid screening approach. Toxicology Mechanisms and Methods 2019;29(1):35-42. doi: 10.1080/15376516.2018.1506850
Badée J, Fowler S, de Wildt SN, Collier AC, Schmidt S, Parrott N. An overview of current knowledge and recommendations for future ontogeny profiling of UDP-glucuronosyltransferase enzymes and its application in improving paediatric dose selection through physiologically based pharmacokinetic modelling. Clinical Pharmacokinetics 2019;58(2):189-211. doi: 10.1007/s40262-018-0681-2.
Dolz-Pérez I, Sallam MA, Masiá E, Morelló-Bolumar D, Pérez Del Caz MD, Graff P, Abdelmonsif D, Hedtrich S, Nebot VJ, Vicent MJ.: Polypeptide-corticosteroid conjugates as a topical treatment approach to psoriasis. J Control Release. 2019; 318:210-222.
Zabihi F, Koeppe H, Achazi K, Hedtrich S, Haag R.: One-Pot Synthesis of Poly(glycerol- co-succinic acid) Nanogels for Dermal Delivery. Biomacromolecules; 20: 1867-1875.
Elpelt A, Albrecht S, Teutloff C, Hüging M, Saeidpour S, Lohan SB, Hedtrich S, Meinke MC.: Insight into the redox status of inflammatory skin equivalents as determined by EPR spectroscopy. Chem Biol Interact. 310: 108752.
Hörst K., van der Broeck L., Erdmann G., Klein O., von Fritschen U., Gibbs S., *Hedtrich S.: Regenerative potential of adipocytes in hypertrophic scars is mediated by myofibroblast reprogramming via BMPs. J Mol Med (Berl). 97: 761-775.
Theune L., Charbaji R., Kar M., Wedepohl S., Hedtrich S., Calderon M.: Critical parameter for the controlled synthesis of nanogels suitable for temperature-triggered protein delivery. Mater Sci Eng C. 100: 141-151.
Gao L., Zabihi F., Ehrmann S., Hedtrich S., *Haag R.: Supramolecular nanogels fabricated via host-guest molecular recognition as penetration enhancer for dermal drug delivery. J Control Release. 300: 64-72.
Khiao In M, Richardson KC, Loewa A, Hedtrich S., Kaessmeyer S, Plendl J.: Histological and functional comparisons of four anatomical regions of porcine skin with human abdominal skin. Anat Histol Embryol, doi:10.1111/ahe.12425.
Albrecht S, Elpelt A, Kasim C, Reble C, Mundhenk L, Pischon H, Hedtrich S., Witzel C, Lademann J, Zastrow L, Beckers I, Meinke MC.: Quantification and characterization of radical production in human, animal and 3D skin models during sun irradiation measured by EPR spectroscopy. Free Radic Biol Med, 131: 299-308.
Plank, R., Yealland, G., Miceli, E., Graff, P., Eckl, K., Cunha, D.L., Gruber, R., Moosbrugger-Martinez, V., Calderon, M., *Hennies, H.C., *Hedtrich, S.: Transglutaminase 1 replacement therapy successfully mitigates the ARCI phenotype in full-thickness skin disease equivalents. J Invest Dermatol, 139: 1191-1195
Maharaj AR, Wu H, Zimmerman KO, Speicher DG, Sullivan JE, Watt K, Al-Uzri A, Payne EH, Erinjeri J, Lin S, Harper B, Melloni C, Hornik CP. Dosing of Continuous Fentanyl Infusions in Obese Children: A Population Pharmacokinetic Analysis. J Clin Pharmacol. 2019 Dec 8;. doi: 10.1002/jcph.1562.
Thompson EJ, Wu H, Maharaj A, Edginton AN, Balevic SJ, Cobbaert M, Cunningham AP, Hornik CP, Cohen-Wolkowiez M. Physiologically Based Pharmacokinetic Modeling for Trimethoprim and Sulfamethoxazole in Children. Clin Pharmacokinet. 2019 Jul;58(7):887-898. doi: 10.1007/s40262-018-00733-1.
Maharaj AR, Wu H, Hornik CP, Cohen-Wolkowiez M. Pitfalls of using numerical predictive checks for population physiologically-based pharmacokinetic model evaluation. J Pharmacokinet Pharmacodyn. 2019 Jun;46(3):263-272. doi: 10.1007/s10928-019-09636-5.
Tarailo-Graovac M, Zahir FR, Zivkovic I, Moksa M, Selby K, Sinha S, et al. De novo pathogenic DNM1L variant in a patient diagnosed with atypical hereditary sensory and autonomic neuropathy. Mol Genet Genomic Med. 2019 Oct;7(10):e00961.
Wang F, Pulinilkunnil T, Flibotte S, Nislow C, Vlodavsky I, Hussein B, et al. Heparanase protects the heart against chemical or ischemia/reperfusion injury. J Mol Cell Cardiol. 2019 Jun;131:29–40.
Tigchelaar S, Gupta R, Shannon CP, Streijger F, Sinha S, Flibotte S, et al. MicroRNA Biomarkers in Cerebrospinal Fluid and Serum Reflect Injury Severity in Human Acute Traumatic Spinal Cord Injury. J Neurotrauma. 2019 Aug 1;36(15):2358–71.
Giaever G, Lissina E, Nislow C. Network dynamics of the yeast methyltransferome. Microb Cell. 2019 Jul 9;6(8):356–69.
Nawrotek A, Benabdi S, Niyomchon S, Kryszke M-H, Ginestier C, Cañeque T, et al. PH-domain- binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling. Nat Chem Biol. 2019 Apr;15(4):358–66.
Hippman C, Nislow C. Pharmacogenomic Testing: Clinical Evidence and Implementation Challenges. J Pers Med. 2019 Aug 7;9(3).
Thiombane NK, Coutin N, Berard D, Tahvildari R, Leslie S, Nislow C. Single-cell analysis for drug development using convex lens-induced confinement imaging. Biotechniques. 2019 Nov;67(5):210–7.
Leitao Filho FS, Alotaibi NM, Ngan D, Tam S, Yang J, Hollander Z, et al. Sputum Microbiome Is Associated with 1-Year Mortality after Chronic Obstructive Pulmonary Disease Hospitalizations. Am J Respir Crit Care Med. 2019 May 15;199(10):1205–13.
Ellison MA, Lederer AR, Warner MH, Mavrich TN, Raupach EA, Heisler LE, et al. The Paf1 Complex Broadly Impacts the Transcriptome of Saccharomyces cerevisiae. Genetics. 2019 Jul;212(3):711–28.
Puri, K., Lal, N., Shang, R., Ghosh, S., Flibotte, S., Dyer, R., Hussein, B., and Rodrigues, B. Diabetes mellitus severity and a switch from using lipoprotein lipase to adipose-derived fatty acid results in a cardiac metabolic signature that embraces cell death. J Am Heart Assoc. 5;8(21):e014022, 2019.
Wang, F., Pulinilkunnil, T., Flibotte, S., Nislow, C., Vlodavsky, I., Hussein, B., and Rodrigues, B. Heparanase protects the heart against chemical or ischemia/reperfusion injury. J. Mol. Cell. Cardiol. 131: 29-40, 2019.
Padda RS, Deng FK, Brett SI, Biggs CN, Durfee P, Brinker CJ, Williams KC, Leong HS. Nanoscale flow cytometry to distinguish subpopulations of prostate extracellular vesicles in patient plasma. Prostate. 2019 May;79(6):592-603.
Williams KC*, Cepeda MA, Javed S, Searle K, Soukhtehzari S, Parkins K, Makela A, Hamilton AM, Kim Y, Tuck AB, Ronald JA, Foster PJ, Chambers AF, Leong HS*. Invadopodia are Chemosensing Protrusions that Guide Cancer Cell Extravasation to Promote Brain Tropism in Metastasis. Oncogene. 2019 Jan 16. *Corresponding Authors
Krstic M, Kolendowski B, Cecchini MJ, Postenka CO, Hassan HM, Andrews J, MacMilan C, Williams KC, Leong HS, Torchia J, Chambers AF, Tuck AB. TBX3 promotes progression of pre-invasive breast cancer cells by inducing EMT and directly up-regulating SLUG. J Pathol. 2019 Jan 29.
Renard I, Grandmougin M, Roux A, Yang SY, Lejault P, Pirrotta M, Wong JMY and Monchaud D. Small-molecule affinity capture of DNA/RNA quadruplexes and their identification in vitro and in vivo through the G4RP protocol. Nucleic Acids Res., 47(11):5502-5510 doi: 10.1093/nar/gkz215. (2019).
Padda RS, Deng FK, Brett SI, Biggs CN, Durfee P, Brinker CJ, Williams KC, Leong HS. Nanoscale flow cytometry to distinguish subpopulations of prostate extracellular vesicles in patient plasma. Prostate. 2019 May;79(6):592-603. [IF:3.7, SJR:1.05].
Williams KC*, Cepeda MA, Javed S, Searle K, Soukhtehzari S, Parkins K, Makela A, Hamilton AM, Kim Y, Tuck AB, Ronald JA, Foster PJ, Chambers AF, Leong HS*. Invadopodia are Chemosensing Protrusions that Guide Cancer Cell Extravasation to Promote Brain Tropism in Metastasis. Oncogene. 2019 Jan 16. [IF: 9.3, SJR:3.39].
Krstic M, Kolendowski B, Cecchini MJ, Postenka CO, Hassan HM, Andrews J, MacMilan C, Williams KC, Leong HS, Torchia J, Chambers AF, Tuck AB. TBX3 promotes progression of pre-invasive breast cancer cells by inducing EMT and directly up-regulating SLUG. J Pathol. 2019 Jan 29. [IF:9.8, SJR:2.53].
Renard I, Grandmougin M, Roux A, Yang SY, Lejault P, Pirrotta M, Wong JMY and Monchaud D. Small-molecule affinity capture of DNA/RNA quadruplexes and their identification in vitro and in vivo through the G4RP protocol. Nucleic Acids Res., 47(11):5502-5510 doi: 10.1093/nar/gkz215. (2019)
2018
Kiang TKL, Partovi N, Shapiro RJ, Berman JM#, Collier AC, Ensom MHH. Regression and genomic analyses on the association between mycophenolic acid exposure and absolute neutrophil count in steroid-free, de novo kidney transplantrecipients. Clinical Drug Investigation 2018 Nov;38(11):1011-1022. doi: 10.1007/s40261-018-0694-5.
Price HR, Collier AC and Wright TE. Screening pregnant women and their neonates for illicit drug use: consideration of the integrated technical, medical, ethical, legal and social issues. Frontiers in Pharmacology. 2018 Aug 28;9:961. doi: 10.3389/fphar.2018.00961
Oeser SG, Bingham J-P and Collier AC. Regulation of hepatic UGT2B15 by methylation in adults of Asian descent. Pharmaceutics 2018;10(1). pii: E6. doi: 10.3390/pharmaceutics10010006.
Walia G, Smith AD, Riches Z, Collier AC, Coughtrie MWH. The Effects of UDP-sugars, UDP, and Mg2+ on uridine diphosphate glucuronosyltransferase activity in human liver microsomes. Xenobiotica 48, 882-890 (2018).
Jager J, Obst K, Lohan SB, Viktorov J, Staufenbiel S, Renz H, Unbehauen M, Haag R, Hedtrich S, Teutloff C, Meinke MC, Danker K, Dommisch H: Characterization of hyperbranched core-multishell nanocarriers as an innovative drug delivery system for the application at the oral mucosa. J Periodontal Res; 53: 57-65.
Guilbidugian, M., Yealland, G., Hönzke, S., Edlich, A., Geisendörfer, B., Kleuser, B., *Hedtrich, S., *Calderon, M.: Breaking the barrier - potent anti-inflammatory activity following efficient topical delivery of etanercept using thermoresponsive nanogels. Theranostics. 8: 450-463.
Sonzogni, A. S., Yealland, G., Kar, M., Wedepohl, S., Gugliotta, L.M., Gonzalez, V.D.G., Hedtrich, S., Calderon, M., Minari, R.J.: Effect of delivery platforms structure on the epidermal antigen transport for topical vaccination. Biomacromolecules, doi: 10.1021/acs.biomac.8b01307.
Löwa, A., Vogt, A., Kaessmeyer, S., *Hedtrich, S.: Generation of full-thickness skin equivalents using hair follicle-derived primary human keratinocytes and fibroblasts. J Tissue Eng Regen Med, 12: e2134-e2146.
Zabihi F., Graff P., Schumacher F., Kleuser B., *Hedtrich, S., *Haag, R.: Synthesis of poly(lactideco-glycerol) as a biodegradable and biocompatible polymer with high loading capacity for dermal drug delivery. Nanoscale. 10: 16848-16856.
Edlich A, Volz P, Brodwolf R, Unbehauen M, Mundhenk L, Gruber AD, Hedtrich, S., Haag, R., Alexiev, U., Kleuser, B.: Crosstalk between core-multishell nanocarriers for cutaneous drug delivery and antigen presenting cells of the skin. Biomaterials. 162: 60-70
Guenther, F., Maus, D., Hedtrich, S., Melzig, M.: Serine Protease Mauritanicain from Euphorbia mauritanica and Phorbol-12-myristate-13-acetate Modulate the IL-8 Release in Fibroblasts and HaCaT Keratinocytes. Planta Med. doi: 10.1055/a-0735-9911.
Zhong B, Maharaj A, Davis A, Roussel MF, Stewart CF. Development and validation of a sensitive LC MS/MS method for the measurement of the checkpoint kinase 1 inhibitor prexasertib and its application in a cerebral microdialysis study. J Pharm Biomed Anal. 2018 Jul 15;156:97-103. doi: 10.1016/j.jpba.2018.04.018.
Maharaj AR, Gonzalez D, Cohen-Wolkowiez M, Hornik CP, Edginton AN. Improving Pediatric Protein Binding Estimates: An Evaluation of α1-Acid Glycoprotein Maturation in Healthy and Infected Subjects. Clin Pharmacokinet. 2018 May;57(5):577-589. doi: 10.1007/s40262-017-0576-7.
Xu S, Tsai A, Sze MA, Vucic EA, Shaipanich T, Harris M, et al. Decreased microbiome diversity in the HIV small airway epithelium. Respir Res. 2018 Jul 27;19(1):140.
Tiefenbach J, Magomedova L, Liu J, Reunov AA, Tsai R, Eappen NS, et al. Idebenone and coenzyme Q(10) are novel PPARα/γ ligands, with potential for treatment of fatty liver diseases. Dis Model Mech. 2018 Aug 31;11(9).
Hammond TG, Allen PL, Gunter MA, Chiang J, Giaever G, Nislow C, et al. Physical Forces Modulate Oxidative Status and Stress Defense Meditated Metabolic Adaptation of Yeast Colonies: Spaceflight and Microgravity Simulations. Microgravity Sci Technol. 2018;30(3):195– 208.
Page MM, Skovsø S, Cen H, Chiu AP, Dionne DA, Hutchinson DF, et al. Reducing insulin via conditional partial gene ablation in adults reverses diet-induced weight gain. FASEB J. 2018 Mar;32(3):1196–206.
Chiu, A. P., Bierende, D., Lal, N., Wang, F., Wan, A., Vlodavsky, I., Hussein, B., and Rodrigues, B. Dual effects of hyperglycemia on endothelial cells and cardiomyocytes to enhance coronary LPL activity. Am. J. Physiol. 314: 82-94, 2018.
Page, M. M., Skovsø, S., Cen, H., Chiu, A., P., Dionne, D., A., Hutchinson, D. F., Lim, G. E., Szabat, M., Flibotte, S., Sinha, S., Nislow, C., Rodrigues, B., and Johnson, J.D. Reducing insulin via conditional partial gene ablation in adults reverses diet-induced weight gain. FASEB J. 32:1196-1206, 2018.
Lal, N., Puri, K., and Rodrigues, B. Vascular endothelial growth factor B and its signaling. In: Novel concepts in cardiac energy metabolism: from biology to disease. Frontiers in Cardiovascular Medicine; Section Cardiovascular Metabolism. Eds., Pulinilkunnil, T., Kienesberger, P., and Nagendran, J. 5: 39, 2018.
Bartlett, J., Trevedi, P., Rodrigues, B., and Pulinilkunnil, T. Myocardial insulin signaling and autophagy. In: Autophagy and Cardiometabolic Diseases: From Mechanisms to Molecules to Medicine. Eds., Jun, R., Sowers, J. R., and Zhang, Y. Elsevier, Amsterdam, Netherlands 1: 101-115, 2018.
Gomes J*, Lucien F*, Cooper TT, Kim Y, Williams KC, Liao X, Kaufman L, Lagugne-Labarthet F, Kenyon O, Boysen J, Kay NE, McIntrye CW, Leong H. Analytical Considerations in Nanoscale Flow Cytometry of Extracellular Vesicles to Achieve Data Linearity. Thrombosis and Haemostasis. 2018. Sep;118(9):1612-1624.
Yang SY, Lejault P, Chevrier S, Boidot R, Robertson AG, Wong JMY* and Monchaud D*. Transcriptome-wide identification of transient RNA G-quadruplexes in human cells. Nat Comm, 9(1):4730. doi: 10.1038/s41467-018-07224-8 (2018). * co-senior authors
Thompson CAH, Gu A, Yang SY, Mathew V, Fleisig HB, Wong JMY. Transient Telomerase Inhibition with Imetelstat Impacts DNA Damage Signals and Cell-Cycle Kinetics. Mol Cancer Res, 16(8):1215-1225. doi: 10.1158/1541-7786. (2018).
Gomes J±, Lucien F±, Cooper TT, Kim Y, Williams KC, Liao X, Kaufman L, Lagugne-Labarthet F, Kenyon O, Boysen J, Kay NE, McIntrye CW, Leong H. Analytical Considerations in Nanoscale Flow Cytometry of Extracellular Vesicles to Achieve Data Linearity. Thrombosis and Haemostasis. 2018. Sep;118(9):1612-1624. [IF:6.3, SJR:1.74].
Yang SY, Lejault P, Chevrier S, Boidot R, Robertson AG, Wong JMY* and Monchaud D*. Transcriptome-wide identification of transient RNA G-quadruplexes in human cells. Nat Comm, 2018 Nov 9;9(1):4730. doi: 10.1038/s41467-018-07224-8. * co-senior authors
Thompson CAH, Gu A, Yang SY, Mathew V, Fleisig HB, Wong JMY. Transient Telomerase Inhibition with Imetelstat Impacts DNA Damage Signals and Cell-Cycle Kinetics. Mol Cancer Res, 16(8):1215-1225. doi: 10.1158/1541-7786. (2018).