Nicole Krentz PhD
Dr. Nicole Krentz is an assistant professor in Molecular and Systems Pharmacology at the Faculty of Pharmaceutical Sciences. The Krentz lab combines human genetics and developmental biology to study the molecular mechanisms underlying the genetic contribution to diabetes risk. The Krentz lab uses innovative approaches, including mouse models of organogenesis, genome editing, stem and progenitor cell differentiation to multiple lineages, and multi-omics analyses, to study how metabolic cells normally develop and how defects in this process leads to disease.
Dr. Krentz received her BSc in cell biology and genetics and her PhD in cell and developmental biology from the University of British Columbia. Her PhD thesis focused on cell cycle regulation of mouse and human pancreas development. Dr. Krentz completed her first postdoctoral fellowship at the Wellcome Centre for Human Genetics at the University of Oxford where she studied how genetic variation impacts human beta cell development and diabetes risk. For her second postdoctoral fellowship, she trained in the Department of Pediatrics at Stanford University and investigated diabetes risk loci with pleiotropic effects across multiple developmental lineages.
KK Mattis*, NAJ Krentz*, C Metzendorf, F Abaitua, AF Spigelman, H Sun, JM Ike, S Thaman, AK Rottner, A Bautista, E Mazzaferro, M Perez-Alcantara, JE Manning Fox, JM Torres, A Weslowska-Andersen, GZ Yu, A Mahajan, A Larsson, PE MacDonald, B Davies, M den Hoed, AL Gloyn (2023). Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression. Diabetologia. 66(4):674*-694. *equal contribution
HH Lau*, NAJ Krentz*, F Abaitua, M Perez-Alcantara, JW Chan, J Ajeian, S Ghosh, B Champon, H Sun, A Jha, S Hoon, NS Tan, D Gardner, SL Kao, ES Tai, AL Gloyn#, AKK Teo# (2022). PAX4 loss of function alters human endocrine cell development and influences diabetes risk. bioRxiv. *equal contribution #corresponding authors
NAJ Krentz, LD Shea, MO Huising, JAM Shaw (2021). Restoring normal islet mass and function in type 1 diabetes through regenerative medicine and tissue engineering. Lancet Diabetes & Endocrinology. 9(10):708-724.
NAJ Krentz#, AL Gloyn# (2020). Insights into pancreatic islet cell dysfunction from type 2 diabetes mellitus genetics. Nature Reviews Endocrinology. 16(4):202-212. #corresponding authors
NAJ Krentz#, MYY Lee, EE Xu, SLJ Sproul, A Maslova, S Sasaki, FC Lynn# (2018). Single-cell transcriptome profiling of mouse and hESC-derived pancreatic progenitors. Stem Cell Reports. 11(6):1551-1564. #corresponding authors
Maternal and Child Health Research Institute Postdoctoral Fellowship, Stanford University, 2021-2023
Robert Turner Research Associate, Green Templeton College at University of Oxford, 2019
Postgraduate Scholarship, Natural Sciences and Engineering Research Council (NSERC), 2015-2017
“Exploring pleiotropic effects of T2D-risk alleles in RREB1 using in vitro and in vivo models.” NAJ Krentz. Australasian Diabetes Congress 2022. Melbourne, Australia (virtual). August 2022.
“Insights into metabolic tissue development & function from human genetics.” NAJ Krentz. Stanford Maternal Child Health Research Institute Seminar Series. Stanford, CA. April 2022.
“Identifying mechanisms for T2D GWAS variants in iPSCs.” NAJ Krentz. EASD Islet Study Group and Beta-Cell Workshop. Oxford, UK. March 2019.
“Single Cell Transcriptome Profiling of the Mouse and Human Endocrine Pancreas Lineages.” NAJ Krentz, EE Xu, FC Lynn. Keystone Frontiers in Islet Biology and Diabetes. Keystone, CO. February 2018.