Hao-Yuan Hung BSc (Pharm), PhD
Visiting Faculty Member
(He, Him, His)
Dr. Hao-Yuan Hung is currently a Visiting Professor in the Faculty of Pharmaceutical Sciences at the University of British Columbia. He is also an Assistant Professor in the Department of Pharmacology at the National Defense Medical University (NDMU), Taipei, Taiwan. Dr. Hung received his BS in Pharmacy, MS in Pharmacology, and PhD in Medical Sciences from NDMU. Prior to his faculty appointment, he worked as a clinical pharmacist at Tri-Service General Hospital.
Dr. Hung’s research lies at the intersection of pharmacology and neuroscience, with a focus on alcohol use disorder and withdrawal syndrome, neuroinflammation, and neurodegenerative diseases. His work integrates animal models, cellular systems, and molecular approaches to investigate GABAergic signaling, microglia-mediated neurotoxicity, and exosome-based biomarkers, particularly in Parkinson’s disease. In parallel, he is actively involved in the development of next-generation analgesics, including opioid receptor modulators with improved efficacy and safety profiles.
His research program has been supported by competitive funding from the National Science and Technology Council of Taiwan, where he serves as Principal Investigator or Co-Principal Investigator on multiple projects. Dr. Hung is the inventor of a granted patent on erythrocyte-derived exosome-based diagnostics for Parkinson’s disease, and has received consecutive National Innovation Awards from Taiwan.
Lin BJ, Hung HY, Kuan-Yin Tseng KY, Hueng DY, Chen YH, Ju DT, Ma HI, Liu MY, Wang HJ. A descriptive analysis of endoscope-assisted endonasal, transorbital, and transcanal transpetrosal approaches to the pons. World Neurosurg X. 2026 Jan 7:100566.
Hung HY, Shih CC, Liao MH, Chen SJ, Huang HC, Wu CC. NKCC1 Inhibition as a Breakthrough in Combating Coagulopathy and Boosting Survival in LPS-Induced DIC Rat Model. Eur J Pharmacol. 2025 Nov 6:178348.
Hung HY, Li IH, Lin YN, Yeh TY, Ng KX, Wang TA, Hong KT, Wang TH, Wu YC, Shih JH. Targeting KCNN4 channels modulates microglial activation and apoptosis in a PD-relevant inflammatory model. Biomed Pharmacother. 2025 Oct;191:118526.
Cheng NJ, Hung HY, Chung TT, Song WS, Hong KT, Hueng DY. Prognostic value of SERPINA1 as a biomarker for poor survival of gliomas. J Med Sci. 2025;45(3):77–85.
Liu TT, Liu CT, Li IH, Chu YC, Hung HY, Chiu CH, Chou TK, Li SY, Wang TA, Shih JH. C18:0 GM3 ganglioside's efficacy in LPS-induced parkinsonism: neuroprotection, inflammatory inhibition and gliosis mitigation. Behav Brain Funct. 2025 Jul 26;21(1):25.
Wang TA, Li SY, Fann LY, Li IH, Liu TT, Hung HY, Chang CW, Cheng CC, Huang YC, Yu PY, Shih JH. Neuroprotective potential of isofraxidin: Alleviating parkinsonian symptoms, inflammation and microglial activation. J Cent Nerv Syst Dis. 2025 Jan 9;17:11795735241312661.
Lai ZZ, Yen IC, Hung HY, Hong CY, Lai CW, Lee YM. In Vitro Antiviral Activity of Rhodiola crenulata Extract against Zika Virus and Japanese Encephalitis Virus: Viral Binding and Stability. Pharmaceuticals (Basel). 2024 Jul 26;17(8):988.
Chen YL, Lai YH, Huang EY, Wang HJ, Hung HY. Nalbuphine-6-glucuronide is a potent analgesic with superior safety profiles by altering binding affinity and selectivity for mu-/kappa-opioid receptors. Life Sci. 2024;340:122441.
Chow LH, Chen YH, Chen YJ, Hung HY, Lin PC, Huang EY. Intrathecal injections of angiotensin IV and oxytocin conjugates induce antihyperalgesia and antiallodynia in both sexes of rats. Peptides. 2024;173:171150.
Li IH, Liu TT, Chen YC, Hsiao SH, Hung HY, Fann LY, Shih JH. Therapeutic effects of methimazole on 3,4-methylenedioxymethamphetamine-induced hyperthermia and serotonergic neurotoxicity. Biomed Pharmacother. 2023 Aug;164:114880.
Huang EY, Hung HY, Chen YH, Kao JH, Tsai AL, Chow LH. Effects of Dextromethorphan on Nicotine-Induced Reward, Behavioral Sensitization, Withdrawal Signs, and Drug Seeking-Related Behavior in Rats. Nicotine Tob Res. 2023 Jun 9;25(7):1251–1260.
Huang HK, Lin PC, Huang TT, Hung HY, Huang TW, Huang EY. Nicotine activates HIF-1α and regulates acid extruders through the nicotinic acetylcholine receptor to promote the Warburg effect in non-small cell lung cancer cells. Eur J Pharmacol. 2023 Jul 5;950:175778.
Wang WL, Wang SY, Hung HY, Chen MH, Juan CH, Li CT. Safety of transcranial magnetic stimulation in unipolar depression: A systematic review and meta-analysis of randomized-controlled trials. J Affect Disord. 2022 Mar 15;301:400–425.
Wang WL, Hung HY, Chung CH, Hsu JW, Huang KL, Chan YY, Chien WC, Chen MH. Risk of Personality disorders among childhood maltreatment victims: A nation-wide population-based study in Taiwan. J Affect Disord. 2022 May 15;305:28–36.
Chow LH, Wu WC, Kuo CL, Hung HY, Chen YH, Pan W, Huang EY. Estrogen can abolish oxytocin-induced spinal anti-hyperalgesia. Psychoneuroendocrinology. 2022 Feb;136:105603.
Hung HY, Chien, WC, Chung, CH, Kao LT, Chow LH, Kotlinska JH, Drabik A, Silberring J, Chen YH, Huang EY. Patients With Alcohol Use Disorder Increase Pain and Analgesics Use. Drug Alcohol Depend. 2021 Dec 1;229(Pt A):109102.
Mielczarek P, Hartman K, Drabik A, Hung HY, Huang EY, Gibula-Tarlowska E, Kotlinska JH, Silberring J. Hemorphins-From Discovery to Functions and Pharmacology. Molecules. 2021 Jun 25;26(13):3879.
Hung HY, Chow LH, Kotlinska JH, Drabik A, Silberring J, Chen YH, Huang EY. LVV-hemorphin-7 (LVV-H7) plays a role in antinociception in a rat model of alcohol-induced pain disorders. Peptides. 2021 Feb;136:170455.
Wang WL, Hung HY, Chen YR, Chen KH, Yang SN, Chu CM, Chan YY. Effect of Foot Reflexology Intervention on Depression, Anxiety, and Sleep Quality in Adults: A Meta-Analysis and Metaregression of Randomized Controlled Trials. Evid Based Complement Alternat Med. 2020 Sep 15;2020:2654353.
Chang YC, Hung HY, Hsiao PJ, Chan JS, Lo CH, Wu CC. Clinical, Laboratory, and Radiological Characteristics of Encapsulating Peritoneal Sclerosis: A Single-Center Experience. Acta Nephrologica 2020, 34(4): 155–164.
21st National Innovation Progress Award, Taiwan, 2024.
20th National Innovation Award, Taiwan, 2023.
Outstanding Mentor of the Year Award at National Defense Medical University, Taipei, Taiwan, 2022.
RBC-Derived Exosomes Enriched with α1-Antichymotrypsin and α1-Antitrypsin: A Novel Biomarker for Parkinson‘s Disease and Contributor to Neuronal α-Synucleinopathy. Multiomics and Precision Medicine Joint Conference Taipei, Taiwan. November 08, 2025.
α6GABAAR positive allosteric modulator as a novel therapy for alcohol withdrawal syndrome. The 35th CINP World Congress (Collegium Internationale Neuro-Psychopharmacologicum). Tokyo, Japan. May 26, 2024.
NKCC1 as a potential therapeutic target for alleviating coagulopathy, multiple organ failure, and sepsis mortality. Institute of Biomedical Sciences, Academia Sinica. Taipei, Taiwan. October 26, 2023.
