Jennifer Brown BSc(Hons), BEd, PhD
Assistant Professor of Teaching, tenure-track (She, Her, Hers)
Dr. Jennifer Brown (She, Her, Hers) obtained her BSc (Hons) in biochemistry and molecular biology from Trent University and her BEd from Queen’s University. She completed her PhD in the Faculty of Pharmaceutical Sciences at UBC with Dr. Adam Frankel, where her research focused on elucidating the mechanisms of protein arginine N-methyltransferases and their implications in biological pathways. During her postdoctoral training with Dr. Brent Page within the Faculty, she brought biochemistry and biological expertise to exploring the anti-cancer activities of novel dihydrofolate reductase inhibitors.
Dr. Brown is a dedicated and passionate science educator. Throughout her post-secondary career, she has been engaged in teaching duties and educational leadership across UBC. She served as the Lead Facilitator of Graduate Student Programs with the Centre for Teaching, Learning, and Technology, where she managed a team of facilitators and developed and delivered instructional skills training programming. She also held instructional positions teaching educational development and chemistry. Dr. Brown’s career goal is to use her scientific knowledge, training and practice in education, and educational leadership experience to inspire and empower the next generation of scientists and educators. Currently, she is applying her biochemistry and molecular biology expertise to the molecular biology lab in PHAR 304 and her skills development expertise to teaching science communication skills in PHAR 480.
Jennifer I. Brown, Rosanne Persaud, Petar Iliev, Ujjwala Karmacharya, Sanaz Attarha, Henok Sahile, Jonas E. Olsen, Danielle Hanke, Temilou Idowu, David A. Frank, Adam Frankel, Karla C. Williams, Brent D.G. Page. (2023). Investigating the anti-cancer potential of pyrimethamine analogues through a modern chemical biology lens. European Journal of Medicinal Chemistry. 264:115971. doi: 10.1016/j.ejmech.2023.115971
Jennifer I. Brown, Peng Wang, Alan Y.L. Wong, Boryana Petrova, Rosanne Persaud, Sepideh Soukhtehzari, Melanie Lopez McDonald, Danielle Hanke, Josephine Christensen, Petar Iliev, Weiyuan Wang, Daniel K. Everton, Karla C. Williams, David A. Frank, Naama Kanarek, Brent D.G. Page. (2023). Cycloguanil and analogues potently target DHFR in cancer cells to elicit anti-cancer activity. Metabolites. 13(2):151. doi: 10.3390/metabo13020151
Jennifer I. Brown, Jenah Alibhai, Erica Zhu, Adam Frankel. (2023). Methylarginine efflux in nutrient-deprived yeast mitigates disruption of nitric oxide synthesis. Amino Acids. 55(2):215-233. doi: 10.1007/s00726-022-03220-x
Anne Nguyen, Po-Han Chao, Chun Yat Ong, Elham Rouhollahi, Nojoud Al Fayez, Louis Lin, Jennifer I. Brown, Roland Böttger, Brent Page, Harvey Wong, Shyh-Dar Li. (2022). Chemically engineering the drug release rate of a PEG-paclitaxel conjugate using click and steric hindrance chemistries for optimal efficacy. Biomaterials. 289:121735. doi:10.1016/j.biomaterials.2022.121735
Nojoud Al Fayez, Roland Böttger, Jennifer Brown, Elham Rouhollahi, Shyh-Dar Li. (2022). The mechanism of Hepatocyte-Targeting and safety profile of Phospholipid-Free small unilamellar vesicles. International Journal of Pharmaceutics. 628:122269. doi:10.1016/j.ijpharm.2022.122269
Lisa N. Heppler, Sanaz Attarha, Rosanne Persaud, Jennifer I. Brown, Peng Wang, Boryana Petrova, Isidora Tošić, Foster B. Burton, Yael Flamand, Sarah R. Walker, Jennifer E. Yeh, Roman A. Zubarev, Massimiliano Gaetani, Naama Kanarek, Brent D.G. Page, David A. Frank. (2022). Pyrimethamine inhibits STAT3 transcriptional activity via dihydrofolate reductase. Journal of Biological Chemistry. 298(2):101531. doi: 10.1016/j.jbc.2021.101531
Alexandre Couto e Silva, Celeste Yin-Chieh Wu, Garrett A. Clemons, Christina H. Acosta, Chuck T. Chen, HarLee E. Possoit, Cristiane T. Citadin, Reggie Hui-Chao Lee, Jennifer I. Brown, Adam Frankel, Hung Wen Lin. (2021). Protein arginine methyltransferase 8 can modulate mitochondrial bioenergetics and neuroinflammation after hypoxic stress. Journal of Neurochemistry. 159(4):742-761. doi: 10.1111/jnc.15462
Jennifer I. Brown, Brent D. G. Page, Adam Frankel. (2020). The application of differential scanning fluorimetry in exploring bisubstrate binding to protein arginine N-methyltransferase 1. Methods. 175: 10-23. doi: 10.1016/j.ymeth.2019.11.004 (Cover Feature)
Adam Frankel, Jennifer I. Brown. (2019). Evaluation of kinetic data: what the numbers tell us about PRMTs. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1867(3): 306-316. doi: 10.1016/j.bbapap.2018.10.010
Jennifer I. Brown, Timo Koopmans, Jolinde van Strien, Nathaniel I. Martin, Adam Frankel. (2018). Kinetic analysis of PRMT1 reveals multifactorial processivity and a sequential ordered mechanism. ChemBioChem. 19(1): 85-90. doi:10.1002/cbic.201700521 (Cover Feature and advertised as “Very Important Paper”)
