Molecular and Systems Pharmacology (MSP) is a group of eleven laboratories in the Faculty of Pharmaceutical Sciences. Our group studies the molecular basis of human disease, to identify targets for drug action; we also investigate the mechanisms of drug action, disposition, and metabolism. Using a System Biology approach, we conduct pharmacogenetics and Pharmacogenomics studies to examine genetic determinants and metabolic biomarkers for drug disposition and toxicity, with the goal of improving drug efficacy and safety. We develop physiologically-based pharmacokinetic and pharmacodynamic models to characterize and predict in vivo drug behavior, and validate these models with laboratory and clinical data. Members of the MSP group are engaged in pre-clinical research of cardiovascular and metabolic diseases, including kidney and liver dysfunction, and diabetes. Our group is also studying cancer, age-related disorders, as well as the mechanisms of both common and rare genetic diseases.
MSP members extensively collaborate within the Faculty of Pharmaceutical Sciences and participate in multi-disciplinary teams outside of the Faculty.